Beneficial bateria for supporting intestinal and gastrointestinal health.

• Source of Probiotics
• Helps support intestinal/gastrointestinal health
• Could promote a favorable gut flora
• 10 billion active Colony Forming Units (CFUs)
• Bio- tract^® to help keep the probiotics viable and improve shelf life
• 10 scientifically chosen probiotic strains for comprehensive support:
  • Lactobacillus plantarum
  • Lactobacillus acidophilus
  • Lactobacillus rhamnosus
  • Lactobacillus salivarius
  • Lactobacillus casei
  • Lactobacillus helveticus
  • Bifidobacterium bifidum
  • Bifidobacterium longum
  • Bifidobacterium breve
  • Bifidobacterium infantis

Research shows that Probiotics are important for the following:

• Helps maintain optimal bacterial balance^{2,3,4,8,10,11,12,19,31,32,36}
• Supports a healthy immune system^{2,3,4,5,7,9,11,12,16,23,31,32,39}
• Supports a normal immune response^{2,3,4,5,7,9,11,12,16,23,31,32,39}
• Supports bowel regularity and stomach comfort^{2,4,8,9,10,11,12,15,19,31,32,36,40}
• Supports colon health^{2,4,8,9,10,11,12,15,19,31,32,36,40}
• Supports healthy teeth^1,6,14,33
• Supports healthy vaginal flora^{24,25,26,27,28,29,30,34}
• Supports healthy vaginal pH^{24,25,26,27,28,29,30,34}
• Supports a healthy urinary tract^{24,25,26,27,28,29,30,34}
• Supports the body's normal resistance to yeast^{6,14,20,21,37}
• Supports a healthy upper digestive tract^{6,13,14,17,37}

The aforementioned has not been approved or considered by Health Canada. The aforementioned are findings made in diverse scientific studies regarding this formulation’s probiotics.

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

Vegetarian - This product is vegetarian

Quality Standards - GMP Operations and Standardised Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Potency, Purity and Identity

Probiotics have been called the functional ingredient of the decade. Clinical research has shown their positive impact on immunity, digestive health and much more. Probiotics help maintain a healthy balance of essential bacteria in the gastrointestinal tract, and are increasingly important in the Canadian diet as we continue to rely on processed foods and prescription drugs.

Lactobacillus plantarum
L. plantarum has been used in the process of fermenting foods for hundreds of years. It promotes a normal digestive tract. It is able to promote the proper balance of bacteria destroy pathogens while preserving vital nutrients, antioxidants and vitamins. One of the most amazing talents of L. plantarum is its ability to synthesize L-lysine, an essential amino acid. L. plantarum is able to promote a proper balance of bacteria in the intestine by neutralizing unhealthy bacteria and also by competing for nutrients which the unhealthy bacteria live on. By doing so, harmful bacteria pass harmlessly through the body.

Lactobacillus acidophilus
L. acidophilus is one of the most highly studied and widely used probiotic organisms. It is a strain of lactic acid producing, rod-shaped microbes that have numerous benefits for digestive health. L. acidophilus produces vitamin K, lactase and acidolin, acidolphilin, lactocidin and bacteriocin. Multiple human trials report benefits of L. acidophilus for maintaining vaginal health. Due to the multiple functions of this microorganism, scientists have discovered that administering L. acidophilus orally helps maintain the healthy colonization of bacteriawithin the digestive tract. L. acidophilus has been shown to support digestive functions and support the immune system. The lactase that L. acidophilus creates is an enzyme that supports the normal breakdown of lactose into simple sugars.

Lactobacillus rhamnosus
L. rhamnosus is a strain of probiotics that aids in balancing the gastrointestinal microflora. It is one of the most intensely studied bacteria in the gastrointestinal tract. One of the remarkable things about L. rhamnosus is its ability to tolerate and even thrive in the harsh acidic conditions normally found in the stomach. L. rhamnosus is believed to be of considerable assistance with immune function in healthy adults, particularly in the urinary tract system (acidic condition). Research has shown that L. rhamnosus helps maintain gastric epithelial cell health, supporting the integrity of the stomach lining.

Lactobacillus salivarius
L. salivarius resides in the mouth and small intestine. It has been shown effective in supporting dental health. L. salivarius has the unique ability to support a healthy gastrointestinal tract. Therefore, L. salivarius may also support immune health. 

Lactobacillus casei
L. casei is a rod-shaped species of Lactobacillus found in milk, cheese and dairy. It is a lactic acid producer like other species within the Lactobacillus genus and has been found to assist in the colonization of beneficial bacteria. L. casei is active in a broad temperature and pH range, and can be found naturally in the mouth and intestine of humans. It is a lactase producer which supports the normal breakdown of lactose and promotes optimal digestive health.

Lactobacillus helveticus
L. helveticus has been well studied for many years and is commonly used in the production of Swiss-type cheeses to enhance flavor. Several beneficial probiotic effects are reported, such as the ability to survive in the stomach and to reach the intestine alive, promoting balanced bacteria in the gastrointestinal tract.A number of studies have been conducted in regard to the myriad of potential health benefits offered by L. helveticus. These studies have focused on health topics, such as bone mineral density and bone mineral content, calcium and bone metabolism, arterial flexibility and blood pressure.

Bifidobacterium bifidum
Bifidobacterium are rod-shaped microbes that have been identified as the most important organisms in the intestine for providing barrier protection. Like Lactobacillus, Bifidobacterium are lactic acid-producing microbes found in fermented foods such as yogurt and cheese. Despite the fact that when we are born Bifidobacterium makes up approximately 95 percent of the total gut population, the Bifidobacterium population decreases in our intestines as adults and declines further as we advance in age. B. bifidum is the predominant bacteria strain found in the microflora of breast-fed infants. It is believed that B. bifidum contributes to the gastrointestinal health of breast-fed infants. In addition to barrier protection, research has shown that Bifidobacterium help to suppor the immune system by promoting normal lymphocyte and phagocyte activity. 

Bifidobacterium longum
B. longum is a branched, rod-shaped bacterium that is among the first to colonize the sterile digestive tract of newborn infants. There is evidence that B. longum competes for attachment sites on the intestinal mucosal membrane promoting , the balanced colonization of bacteria. It has a high resistance to gastric acid and shares similar functions as B. bifidum, such as supporting the immune system and providing barrier protection. 

Bifidobacterium breve
B. breve is another branched, rod-shaped bacterium.. B. breve promotes health of the gastrointestinal tract. B. breve is also present in the vagina, where it helps support the body’s normal resistance to yeast. The job of B. breve in the digestive tract is to ferment sugars and produce lactic acid, as well as acetic acid. B. breve is like a champion among probiotic bacteria due to its superior ability to metabolize many types of food.

Bifidobacterium infantis
B. infantis is a probiotic bacterium that inhabits the intestine of both infants and adults. According to a study sponsored by P&G Health Sciences Institute and published in the American Journal of Gastroenterology, B. infantis may be beneficial to promote stomach health and comfort.  B. infantis plays an important role in basic digestion, proper metabolism and overall well-being.

1. How many viable micro-organisms are in Probiotics 10?
   There are 10 billion active probiotic organisms from 10 different strains at time of manufacture.
   
   
2. How do I store Probiotics 10?
   Refrigeration is not necessary, but will ensure maximum potency and shelf life. Do not expose to excessive heat, humidity or direct sunlight.
   
   
3. Why is BIO-tract^® important for this product? 
   Probiotics 10 uses BIO-tract^® technology. This clinically-tested methods help deliver probiotic organisms into the body so that they may work most effectively. BIO-tract^® is a unique delivery system that protects the probiotic organisms throughout your digestive system. This helps ensure that more organisms reach the intestine alive. 
   
   
4. How do the bacteria live in Probiotics 10? Is there any food for them inside?
   The bacteria are in a state of suspended animation. They are dry enough that all biological processes are in a resting state. Once consumed, they rehydrate and biological processes including growth and reproduction resume. So a food source in the tablet is not necessary.
   
   
5. Can Probiotics 10 be taken with Isotonix^® Digestive Enzymes?
   Yes, Probiotics 10 and Isotonix Digestive Enzymes would complement each other when taken together as part of your daily nutritional supplement regimen. These products should not be taken concurrently. Isotonix Digestive Enzymes should be taken with a meal and Probiotics should be taken on an empty stomach between meals.
   
   
6. What other products complement Probiotics 10?
   There are many products which can complement Probiotics 10, depending on your unique goals and needs. For overall digestive health, try the Nutriclean^® 7-Day System with Probiotics 10. For daily digestive health, try pairing Probiotics 10 with Nutriclean^® Advanced Fiber Powder. To support immune health, you could have a regimen of Isotonix OPC-3^®, Isotonix^® Vitamin C and Probiotics 10. Nutriclean branded products and others can be found on GLOBLAL.SHOP.COM.
   
   
7. How should I take Probiotics 10?
   Take 1 tablet daily. If you are on an antibiotic(s), take at least 2-3 hours before or after.
   
   
8. Are there any allergens in Probiotics 10?
   Probiotics 10 contains trace amounts of milk from the fermentation process. There are less than two parts per million (ppm) of milk in each serving. This product is safe for individuals with lactose sensitivity.
   
   
9. How does Probiotics 10 affect digestion?
   There are many components which impact optimal digestive health. They include enzymes (which start breaking down foods in the mouth and are found in the intestines), pH conditions, bile from the gall bladder, intestinal microflora, probiotics and some digestive properties contained in the food that we eat. Diet and supplementing your intestines with probiotics can help support digestion. Well balanced intestinal micro flora will promote healthy digestion.
   
   
10. Can I just eat some yogurt and get the same benefits?
    Yogurt is an excellent source of probiotics, but it’s not for everyone. Some people can’t tolerate dairy, and others simply don’t like the taste. Probiotics 10 provides the goodness of yogurt without the fat, sugar or calories. Plus, the benefits don’t disappear because they encounter stomach acid. That’s because these beneficial bacteria are protected by BIO-tract^® technology. Because of this protection, more of our probiotics move through the intestinal tract unharmed to deliver a significantly greater number of active cultures. They support the growth of beneficial bacteria where it’s needed most, to help digest food and promote a healthy immune system.

1. Bonifait, L., et al. Probiotics for oral health: myth or reality? Journal of the Canadian Dental Association. 75(8): 585-590, 2009.
2. Broekaert, I. and Walker, A. Probiotics and Chronic Disease. Journal of Clinical Gastroenterology. 40(3): 270-274, 2006.
3. Brudnak, M. Probiotics as an adjuvant to detoxification protocols. Medical Hypotheses. 58(5): 382-385, 2002.
4. Douglas, L. and Sanders, M. Probiotics and prebiotics in dietetics practice. Journal of the American Dietetic Association. 108(3): 510-521, 2008.
5. Dugas, B., et al. Immunity and probiotics. Immunology Today. 20(9): 387-390, 1999.
6. Elahi, S., et al. Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus. Brittish Society foe Immunology, Clinical and Experimental Immunology. 141: 29-36, 2005.
7. Erickson, K. and Hubbard, N. Probiotic immunomodulation in health and disease. Journal of Nutrition. 130(2S Suppl): 403S-409S, 2000.
8. Fernandes, C., et al. Control of diarrhea by lactobacilli. Journal of Applied Nutrition. 40: 32-43, 1988.
9. Friedrich, M. A bit of culture for children: probiotics may improve health and fight disease. Journal of the American Medical Association. 284(11): 1365-1366, 2000.
10. Frohmader, T., et al. Decrease in frequency of liquid stool in enterally fed critically ill patients given the multispecies probiotic VSL#3: a pilot trial. American Journal of Critical Care. 19: 1-11, 2010.
11. Gill, H. and Guarner, F. Probiotics and human health: a clinical perspective. Postgraduate Medical Journal. 80(947): 516-526, 2004.
12. Guarner, F. and Malagelada, J. Gut flora in health and disease. Lancet. 361(9356): 512-519, 2003.
13. Guglielmetti, S., et al. Oral bacteria as potential probiotics for the pharyngeal mucosa. Applied and Environmental Microbiology. 76(12): 3948-3958, 2010.
14. Hatakka, K., et al. Probiotics reduce the prevalence of oral candida in the elderly – A randomized controlled trial. Journal of Dental Research. 86(2): 125-130, 2007.
15. Hickson, M., et al. Use of probiotic Lactobacillus preparation to prevent diarrhea associated with antibiotics: randomised double blind placebo controlled trial. British Medical Journal. 335: 80-83, 2007.
16. Isolauri, E., et al. Probiotics: a role in the treatment of intestinal infection and inflammation? Gut. 50: 54-59, 2002.
17. Lambert, J. and Hull, R. Upper gastrointestinal disease and probiotics. Asia-Pacific Journal of Clinical Nutrition. 5: 31-35, 1996.
18. Ljungh, Å., et al. Isolation, selection and characteristics of Lactobacillus paracasei subsp. paracasei F19. Microbial Ecology in Health and Disease. 3: 4-6, 2002.
19. Marteau, P., et al. Protection from gastrointestinal diseases with the use of probiotics. American Journal of Clinical Nutrition. 73(Suppl): 430S-436S, 2001.
20. Noverr, M. and Huffnagle, G. Regulation of Candida albicans morphogenesis by fatty acid metabolites. Infection and Immunity. 72(11): 6206-6210, 2004.
21. Payne, S., et al. In vitro studies on colonization resistance of the human gut microbiota to Candida albicans and the effects of tetracycline and Lactobacillus plantarum LPK. Current Issues in Intestinal Microbiology. 4: 1-8, 2003.
22. Parracho, H., et al. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. Journal of Medical Microbiology. 54: 987-991, 2005.
23. Rastall, R. et al. Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications. FEMS Microbiology Ecology. 52: 145-152, 2005. 
24. Reid, G., et al. Oral probiotics can resolve urogenital infections. FEMS Immunology and Medical Microbiology. 30: 49-52, 2001.
25. Reid, G., et al. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo,-controlled trial in 64 healthy women. 35: 131-134, 2003.
26. Reid, G. Probiotic agents to protect the urogenital tract against infection. American Journal of Clinical Nutrition. 73: 437S-443S, 2001.
27. Reid, G., et al. Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora. FEMS Immunology and Medical Microbiology. 32: 37-41, 2001.
28. Reid, G. The scientific basis for probiotic strains of Lactobacillus. Applied and Environmental Microbiology. 65(9): 3763-3766, 1999.
29. Reid, G. and Burton, J. Use of Lactobacillus to prevent infection by pathogenic bacteria. Microbes and Infection. 4: 319-324, 2002.
30. Ronnquist, PD, Forsgren-Brusk, UB, and Hakansson, EE. Lactobacilli in the female genital tract in relation to other genital microbes and vaginal pH. Acta Obstetricia et Gynecologica. 85: 726-735, 2006
31. Roberfroid, M. Prebiotics and probiotics: are they functional foods? American Journal of Clinical Nutrition. 71(Suppl): 1682S-1687S, 2000.
32. Rolfe, R. The role of probiotic cultures in the control of gastrointestinal health. Journal of Nutrition. 130: 396S-402S, 2000.
33. Shimauchi, H., et al. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study. Journal of Clinical Peridontology. 35: 897-905, 2008.
34. Strus, M., et al. The in vitro activity of vaginal Lactobacillus with probiotic properties against Candida. Infections Dieseses in Obstetrics and Gynecology. 13(2): 69-75, 2005.
35. Szajewska, H. and Mrukowicz, J. Probiotics in the treatment and prevention of acute infectious diarrhea in infants and children: a systematic review of published randomized, double-blind, placebo-controlled trials. Journal of Pediatric Gastroenterology and Nutrition. 33: S17-S25, 2001.
36. Tuohy, K., et al. Using probiotics and prebiotics to improve gut health. Therapeutic Focus. 8(15): 692-700, 2003.
37. Van Der Mei, H.C., et al. Effect of probiotic bacteria on prevalence of yeasts in oropharyngeal biofilms on silicon rubber voice prosthesis in vitro. Journal of Medical Microbiology. 49: 713-718, 2000.
38. Van Niel, W., et al. Lactobacillus therapy for acute infectious diarrhea in children: a meta-analysis. Pediatrics. 109(4): 678-683, 2002.
39. Verdenelli, M., et al. Probiotic properties of Lactobacillus rhamnosus and Lactobacillus paracasei isolated from human feces. European Journal of Nutrition. 48: 355-363, 2009.
40. Wullt, M., et al. Lactobacillus plantarum 299v enhances the concentrations of fecal short chain fatty acids in patients with recurrent Clostridum difficile-associated diarrhea. Digestive Diseases and Sciences. 52: 2082-2086, 2007.